Showing posts with label Medical Study. Show all posts
Showing posts with label Medical Study. Show all posts

Tuesday, February 19, 2019

New Stem Cell Injection Therapy For Tennis Elbow In Australia Looks Promising



A new, cutting edge tendon stem cell injection procedure for Tennis Elbow and other Tendinopathies, utilizing Orthocell's Autologous Tenocyte Injection (ATI) technology, is now being offered in Australia, having undergone at least 2 clinical trials - (Although it's not available in the United States yet.)

Stem Cell Treatment For Tennis Elbow On The Cutting Edge ‘Down Under’ was originally published on: https://tenniselbowclassroom.com (Read the full article there.)

In October of 2013, Orthocell Limited announced the results of a successful clinical trial of a tendon injury treatment, using its patented stem cell technology.

This clinical trial, apparently the first of its kind, was published in the American Journal of Sports Medicine (AJSM)

The way the study was conducted was:
  1. MRI scans taken – Patients with stubborn, severe cases of Tennis Elbow first had MRI scans,

  2. Tendons cells extracted from knee – Tendon cells were taken from the patients' healthy Patellar Tendons by needle biopsy (under local anesthetic)

  3. Tendons cells cultured and multiplied – The cells were expanded by in vitro culture in a lab, to produce larger numbers of tenocytes

  4. Tenocytes injected into damaged Tennis Elbow area – The tenocytes (tendon stem cells) were injected into the site of tendinopathy (the Tennis Elbow tendon ECRB) under ultrasound / sonogram guidance.

  5. Patients were reevaluated – Finally, the patients underwent clinical reevaluations and had follow up MRI scans 1 year after the procedure.

For more, read the full article here

Thursday, February 14, 2019

New Clinical Study Of Bio-Engineered Collagen For Treating Tennis Elbow



CollPlant, an Israeli biotech company recently announced the promising results of a clinical trial of their bioengineered collagen product (combined with Platelet-Rich Plasma Injection Therapy) in the treatment of Tennis Elbow.

The clinical study, which was concluded in August of 2016, was published Nov 26, 2018 in the Journal of Shoulder and Elbow Surgery.

First Clinical Experience With A New Injectable Recombinant Human Collagen Scaffold Combined With Autologous Platelet-Rich Plasma For The Treatment Of Lateral Epicondylar Tendinopathy (Tennis Elbow)

"Based on positive outcomes from preclinical trials, this study is the first clinical trial of STR/PRP on tendinopathy."

"The study enrolled 40 patients. No systemic or local severe adverse events were reported. Clinical evaluation revealed an improvement in the mean Patient-Rated Tennis Elbow Evaluation score from 64.8 before treatment and showed a 59% reduction at 6 months."
  • 28% increase in grip strength,
  • 59% improvement of Patient-Rated Tennis Elbow Evaluation score,
  • 68% showed improvements in tendon appearance via sonographic imaging
Farkash, Uri et al; J. of Shoulder and Elbow Surgery; doi.org/10.1016/j.jse.2018.09.007
https://www.jshoulderelbow.org/article/S1058-2746(18)30697-9/fulltext
New Clinical Study Of Bio-Engineered Collagen For Treating Tennis Elbow was originally published on: https://tenniselbowclassroom.com (Read the full article there.)

Saturday, August 27, 2016

Taking Another Shot At Cortisone For Treating Tennis Elbow

The Cortisone injection as a treatment for Tennis Elbow came under fire again this week by Gretchen Reynolds, of the New York Times, who takes another shot at the idea that Cortisone is a valid 'Quick Fix' for Tennis Elbow. (Is the short-term relief worth the long-term costs?)



In the article, For Tennis Elbow, No Such Thing as a Quick Fix Gretchen begins by affirming the continued popularity of the Cortisone shot as a Tennis Elbow treatment:
"Recent surveys in the United States and Britain show that injections of the steroid, which rapidly dulls pain and fights inflammation, are the preferred first line of treatment among many orthopedic specialists."
And then immediately raises the issue of the risks involved with these shots, referring to the:
"...growing evidence suggests that the injections, while effective in the short term, can frequently worsen the condition in the months that follow..."
She cites a study from Norway published in BioMed Central's Musculoskeletal Disorders Journal, which suggests that Cortisone injections, while effective in the short term for Tennis Elbow (in relieving pain) frequently worsen the condition in the months to come:

http://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891-015-0582-6

This is not the first study showing positive short-term benefits to be followed by negative long-term outcomes. It has been preceded by many other studies and papers going back 20+ years, which suggest that Corticosteroid shots delay healing and weaken tendons.

In an Oct. 2010 New York Times Well Blog post, (for some reason not linked to in the more recent post) Phys Ed: Do Cortisone Shots Actually Make Things Worse?



Gretchen refers to one of those studies, featured in the Lancet:

Efficacy and safety of Corticosteroid Injections and other Injections for Management of Tendinopathy...
"Over all, people who received cortisone shots had a much lower rate of full recovery than those who did nothing or who underwent physical therapy. They also had a 63 percent higher risk of relapse than people who adopted the time-honored wait-and-see approach."
Another point the author makes consistently between these two articles (which I applaud!!) is that the overwhelming evidence shows that Tennis Elbow is a condition marked by degenerative changes and not inflammation, as is so often incorrectly, robotically parroted by medical websites, Doctors P.T.s and other sources and authorities.
"...numerous studies have shown, persuasively, that these overuse injuries do not involve inflammation." [2010 N.Y.T. article]
"Newer science, however, including biopsies of the sore tissues, shows little inflammation, except in the very early stages of the injury. Instead, it is thought to involve degeneration of the tissues..." [2016 N.Y.T. article]
I've been quoting these medical studies, papers and references since the early 2000s myself, trying to make Tennis Elbow and other Tendinopathy sufferers aware that the old "inflammatory model" was dead and gone, and that there is no healing value in "chasing" inflammation with pills, ice and, worst of all, Cortisone Shots.

Regardless of whether inflammation is there or not and whether these so-called treatments "treat" that inflammation effectively or not!

It doesn't matter. Inflammation is an aspect of the healing process, anyway!

It's an essential, "can't actually heal without it" necessity for which there is NO upside to treating, managing, reducing or otherwise suppressing - especially if one succeeds in completely eradicating it!

The sad thing is that Cortisone is so efficient at blocking and suppressing inflammation (and collagen synthesis, it seems) that it apparently leaves the damaged area at disadvantage - and in the case of multiple shots - possibly a state that is impossible to repair and recover from.

(But you may need to dig a little deeper into the medical studies and their terminology to really get that key knowledge.)

Here's my original article where I discuss that and reference some of those studies if you'd like to learn more:

https://tenniselbowclassroom.com/tennis-elbow-treatments/cortisone-shots-for-treating-tennis-elbow-pain-damaging-ineffective/


Here's my Cortisone Shots podcast episode, above - And you'll find that podcast, as well as my Cortisone video along with the full post, here: (Click image below.)